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Home >> Antibodies >> Pappalysin-1 Antibody / PAPPA

Pappalysin-1 Antibody / PAPPA [clone PAPPA/8804R] (V5305)

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  Catalog No Formulation Size Price (USD)  
Image V5305-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V5305-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V5305SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recrabbitmono
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IHC staining of FFPE human placental tissue with Pappalysin-1 antibody (clone PAPPA/8804R). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human placental tissue with Pappalysin-1 antibody (clone PAPPA/8804R). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Pappalysin-1 antibody (clone PAPPA/8804R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name PAPPA/8804R
Purity Protein A/G affinity
UniProt Q13219
Localization Secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This Pappalysin-1 antibody is available for research use only.
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Description

Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).

Application Notes

Optimal dilution of the Pappalysin-1 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 351-523) from the human protein was used as the immunogen for the Pappalysin-1 antibody.

Storage

Aliquot the Pappalysin-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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